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Powerful new treatment for the pain of osteoarthritis.

Powerful new treatment for the pain of osteoarthritis.

CINGAL® is the first and only approved combination viscosupplement formulated to provide the benefit of a cross-linked hyaluronic acid and a fast acting steroid.

CINGAL® is the first and only approved combination viscosupplement formulated to provide the benefit of a cross-linked hyaluronic acid and a fast acting steroid.

Only CINGAL®

CINGAL® combines Anika’s proprietary cross-linked hyaluronic acid formulation, with proven effects through 6 months, with a well-established FDA approved steroid.

Triamcinolone Hexacetonide (steroid) injections have been used for over 45 years for their potent anti-inflammatory effects, to reduce pain quickly and allow earlier motion. While steroids provide rapid pain relief, the effects are typically short lived.1,2,3

Hyaluronic acid (HA) is a naturally occurring biocompatible molecule found throughout the body and is a vital component of healthy joint and tissue function. HA viscosupplements have been used for more than 25 years to reduce pain associated with osteoarthritis (OA), improve viscoelastic properties of the synovial fluid and protect the surface of articular cartilage.4,5,6,7 While traditional HA injections can deliver long lasting pain relief, the patient does not typically experience the peak effects until 8 weeks after the final injection.1,2,3,11

Only CINGAL® works by combining the best of fast acting steroids with a long-lasting viscosupplement to deliver rapid pain relief proven to last through 6 months.

Only CINGAL® works by combining the best of fast acting steroids with a long-lasting viscosupplement to deliver rapid pain relief proven to last through 6 months.

Only CINGAL® works by combining the best of fast acting steroids with a long-lasting viscosupplement to deliver rapid pain relief proven to last through 6 months.

THE FIRST AND ONLY COMBINATION HA + STEROID

Description

CINGAL® is a novel combination HA plus steroid single-injection treatment for the pain associated with osteoarthritis. CINGAL® combines the high molecular weight cross-linked hyaluronic acid (HA) formulation of MONOVISC® with a corticosteroid for additional short-term pain relief.

Indications

CINGAL® is indicated as a viscoelastic supplement or a replacement for synovial fluid in human joints. CINGAL® is well suited for rapid and long term relief of the symptoms of human joint dysfunctions such as osteoarthritis. The actions of CINGAL® are long term relief of symptoms by lubrication and mechanical support supplemented by short-term pain relief provided by triamcinolone hexacetonide.

Direction for use

The pre-filled syringe is intended for single use only. The contents of the syringe should be used immediately after opening. Discard any unused CINGAL®. Do not resterilize.

• Store at 2 to 25 ̊C. Protect from freezing. Refrigerated CINGAL® should be allowed to reach room temperature (approx. 20-45 min.) prior to use.

• Only medical professionals trained in accepted injection techniques for delivering agents into the knee joint should inject CINGAL® for the indicated use.

Contents

The product contains 22 mg/mL high molecular weight cross- linked hyaluronic acid produced from bacterial fermentation, 4.5 mg/mL triamcinolone hexacetonide.

How Supplied

CINGAL® is supplied as a 4 mL unit dose in a terminally-sterilized 5 mL glass syringe.

CLINICALLY PROVEN

CINGAL® demonstrated clinically significant improvement over saline from the evaluator and patient perception.10

CINGAL® was superior to saline in all WOMAC assessments.10

THE CINGAL® BENEFITS

  • Fast acting pain relief
  • Long lasting pain relief
  • Convenient single-injection treatment
  • Highly concentrated, non-animal based HA
  • Safe and effective

THE CINGAL® PATIENT

  • Demands quick results
  • Prefers a single visit treatment
  • Desires to remain active
  • Looks to delay reconstructive surgery

The Science behind CINGAL®

Micronized particles of the water-insoluble steroid are suspended in the viscoelastic HA gel and reside within CINGAL® as a separate solid phase. Both the HA and steroid remain unchanged by incorporation into the CINGAL® formulation and by sterilization.9

The Science behind CINGAL®

Micronized particles of the water-insoluble steroid are suspended in the viscoelastic HA gel and reside within CINGAL® as a separate solid phase. Both the HA and steroid remain unchanged by incorporation into the CINGAL® formulation and by sterilization.9

Fast Acting. Long Lasting.

CINGAL® is a powerful, first in class treatment that combines the proven benefits of Anika’s proprietary high concentration cross-linked hyaluronic acid formulation, approved for long-term pain relief, with a well-established FDA-approved steroid to treat inflammation. This unique combination provides rapid pain relief that lasts through 6 months.

Fast Acting. Long Lasting.

CINGAL® is a powerful, first in class treatment that combines the proven benefits of Anika’s proprietary high concentration cross-linked hyaluronic acid formulation, approved for long-term pain relief, with a well-established FDA-approved steroid to treat inflammation. This unique combination provides rapid pain relief that lasts through 6 months.

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